Zhiqun Tan

Single-probe, high-yield spatial mapping of diverse short RNA motifs

The paper introduces SMOOTHY-FISH, a method to visualize short RNA motifs at single-molecule resolution, revealing new spatial RNA biology insights in single cells and mouse brain tissues.

Nmur1 and Cckar fail to support functional genetic access in adult dopamine neurons and challenge GPCR atlas assignments

The paper shows that proposed GPCR markers for adult dopamine neurons, like Nmur1 and Cckar, lack functional expression and challenge existing atlas assignments.

UC Irvine Brain Initiative Cell Atlas Network (BICAN) Brain Procurement Program for the Center for Multiomic Human Brain Cell Atlas Project

The paper describes a multi-institutional program for collecting neurotypical human brains to support multiomic brain cell atlas studies, highlighting challenges and opportunities for donor recruitment.

Multiscale Spatial Transcriptomic Atlas of Human Basal Ganglia Cell-Type and Cellular Community Organization

This paper creates a high-resolution spatial transcriptomic atlas of the human basal ganglia, identifying 60 cell types and their spatial organization across multiple nuclei.

Establishing a continuum of cell types in the visual cortex

The paper shows that the L2/3 continuum in the mouse visual cortex develops through two phases: a genetically programmed initial phase and a visually experience-driven second phase.

Spatial profiling of the interplay between cell type- and vision-dependent transcriptomic programs in the visual cortex

The paper uses spatial transcriptomics and computational methods to show that vision affects both cell state and cell type composition in the visual cortex during critical periods.

BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences

This study shows that riluzole improves cognitive function and reduces neurodegeneration in mice after cranial radiation therapy by increasing BDNF levels and reducing neuroinflammation.

Sequential increase of PHGDH expression with Alzheimer's pathology and symptoms

The paper shows PHGDH expression increases sequentially with AD pathology and symptoms in mice and humans, correlating with cognitive decline and suggesting PHGDH as a potential biomarker and caution for L-serine therapy.