Annie OF Hiniker

The paper uses multiomic single-cell and spatial data to identify gene regulatory networks and transcription factors driving cortical regionality in the human brain.

The paper examines iron levels and lipid peroxidation in DSAD brains, finding increased iron and lipid damage compared to AD and controls, suggesting ferroptosis involvement.

The paper analyzes bulk RNA-seq data from diverse ethnic groups to identify differentially expressed genes and pathways in Alzheimer's Disease, highlighting cross-ethnic and ethnic-specific findings.

The paper identifies six genetic loci associated with Alzheimer's disease in Hispanics, showing both genetic and epigenetic risks, with some downstream effects on mRNA expression being ethnicity-specific.

The paper shows PHGDH expression increases sequentially with AD pathology and symptoms in mice and humans, correlating with cognitive decline and suggesting PHGDH as a potential biomarker and caution for L-serine therapy.

This study identifies TRIM1 as an E3 ligase that ubiquitinates LRRK2, regulating its localization, degradation, and toxicity in Parkinson's Disease.