Xu Chen

Identification of a Highly Expressed Gene Cluster Likely Coding for Benzene Activation Enzymes in a Methanogenic Enrichment Culture

The paper identifies two gene clusters in a methanogenic enrichment culture that likely code for benzene activation enzymes, providing genetic and proteomic evidence for anaerobic benzene degradation mechanisms.

Dynamic fingerprinting of the human functional connectome

This study develops dynamic brain fingerprinting using state-specific functional connectivity, showing improved individual identification and cognitive prediction compared to static methods.

Automatic binding of basic sensory features requires consciousness

The paper investigates the role of consciousness in binding basic sensory features using sEEG recordings in awake and anesthetized states, finding that consciousness is necessary for feature binding but not for encoding individual attributes.

Highly accurate protein structure prediction-based virtual docking pipeline accelerating the identification of anti-schistosomal compounds

This paper uses AlphaFold for protein structure prediction and virtual screening to identify anti-schistosomal compounds, finding seven active compounds including Carubicin hydrochloride, which targets U2AF65 and disrupts parasite splicing.

Metabolic and ribosomal dysregulation drive developmental arrest of Schistosoma japonicum in non-permissive rats

This study identifies metabolic and ribosomal dysregulation as key factors causing developmental arrest of Schistosoma japonicum in non-permissive rats.

Sequential increase of PHGDH expression with Alzheimer's pathology and symptoms

The paper shows PHGDH expression increases sequentially with AD pathology and symptoms in mice and humans, correlating with cognitive decline and suggesting PHGDH as a potential biomarker and caution for L-serine therapy.