Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit
Annika L. Gustafson, Stephanie Nance, Berkley E. Gryder, Noha A.M. Shendy, Lars Wick, Grace B. McKay-Corkum, K. Elaine Ritter, Stephen Connor Purdy, Arthur R. Wolin, Sheera R. Rosenbaum, Sabateeshan Mathavarajah, Nickerson A. Demelfi, Yueyang Wang, Yang Zhang, Mark W. Zimmerman, , Adam David Durbin
The paper identifies a core regulatory circuit in rhabdomyosarcoma and shows that targeting two co-activators synergistically inhibits tumor growth.
bioRxiv · Sep 3, 2026 · PreprintCancer Biology