The enzyme glutamate-cysteine ligase (GCL) is a target for ferroptosis induction in cancer
John K. Eaton, Priya Chatterji, Laura Furst, Sneha Basak, Ayesha M. Patel, Yan Y. Sweat, Luke L. Cai, Krishna Dave, Rachelle A. Victorio, Elizabeth M. Pizzi, Javad Noorbakhsh, Gaochao Tian, Jennifer A. Roth, John Hynes, Gang Xing, , Vasanthi S. Viswanathan
This study identifies GCL inhibition as a strategy to induce ferroptosis in cancer cells, introducing novel inhibitors with potent cellular activity.
bioRxiv · Apr 28, 2024 · PreprintCancer Biology