A pathogenic AMPAR mutation disrupts hippocampal synapse maturation and homeostasis
Jian Xu, Yi-Zhi Wang, Toshihiro Nomura, Han My Van, Yiwen Zhu, Charlotte Castillon, Morgane Chiesa, John N. Armstrong, John Norman Armstrong, Yongling Zhu, Jeffrey N. Savas, Anis Contractor
This study shows that a pathogenic AMPAR mutation impairs hippocampal synapse maturation and leads to metabolic adaptations over time.
bioRxiv · Sep 30, 2026 · PreprintNeuroscience