Jian Xu

This study shows that a pathogenic AMPAR mutation impairs hippocampal synapse maturation and leads to metabolic adaptations over time.

BLIS-XL-MS enables proteome-wide analysis of structural remodeling in brain tissue by combining experimental and computational methods to study protein conformational changes in neurodevelopmental disorders.

This study shows that mGluR5 modulates co-activity of striatal direct pathway neurons and motor output through synaptic plasticity.

This study shows that an autism-linked mutation in Cacna1d causes perseverative behaviors in mice without affecting anxiety or locomotion.

The paper identifies Ca2+-dependent phosphodiesterase 1 (PDE1) as a regulator of NO-induced long-term depression (NO-LTD) in striatal spiny projection neurons, linking it to synaptic plasticity and Parkinson's disease.

This study investigates a missense mutation in the GRIK2 gene, showing it disrupts SK channel function, leading to increased dendritic excitability and synaptic integration in hippocampal neurons.

The paper describes a method using safe nucleic acid dyes to quickly and reliably quantify Adeno-Associated Virus (AAV) titers.