Author

John N. Armstrong

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:electronic health records· 2 Research Focus:spatial domain detection· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Anis ContractoriD· 4 shared Charlotte CastilloniD· 3 shared Jian XuiD· 3 shared Toshihiro NomuraiD· 3 shared Jeffrey N. SavasiD· 2 shared Nai-Hsing YehiD· 2 shared Anika P. WileniD· 1 shared Geoffrey T. SwansoniD· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersNeuroscience

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4 papers

Recent·Most cited

A pathogenic AMPAR mutation disrupts hippocampal synapse maturation and homeostasis

Jian Xu, Yi-Zhi Wang, Toshihiro Nomura, Han My Van, Yiwen Zhu, Charlotte Castillon, Morgane Chiesa, John N. Armstrong, John Norman Armstrong, Yongling Zhu, Jeffrey N. Savas, Anis Contractor

This study shows that a pathogenic AMPAR mutation impairs hippocampal synapse maturation and leads to metabolic adaptations over time.

bioRxiv · Sep 30, 2026 · PreprintNeuroscience

Subregional activity in the dentate gyrus is amplified during elevated cognitive demands

Charlotte Castillon, Shintaro Otsuka, John N. Armstrong, Anis Contractor

This study shows that increased cognitive demand in mice enhances spatial activity in the suprapyramidal blade of the dentate gyrus, with specific roles for mature and adult-born granule cells.

eLife · May 14, 2026Peer-reviewedNeuroscience

Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output

John J Marshall, Jian Xu, Nai-Hsing Yeh, Seongsik Yun, Toshihiro Nomura, John N. Armstrong, Jones G. Parker, Anis Contractor

This study shows that mGluR5 modulates co-activity of striatal direct pathway neurons and motor output through synaptic plasticity.

eLife · Jan 27, 2026Peer-reviewedNeuroscience

A pathogenic missense mutation in kainate receptors elevates dendritic excitability and synaptic integration through dysregulation of SK channels

Toshihiro Nomura, Sakiko Taniguchi, Yizhi Wang, Nai-Hsing Yeh, Anika P. Wilen, Charlotte Castillon, Kendall M. Foote, Jian Xu, John N. Armstrong, Jeffrey N. Savas, Geoffrey T. Swanson, Anis Contractor

This study investigates a missense mutation in the GRIK2 gene, showing it disrupts SK channel function, leading to increased dendritic excitability and synaptic integration in hippocampal neurons.

Journal of Neuroscience · Oct 6, 2023Peer-reviewedNeuroscience