Anis Contractor

This study investigates how movement refinement and cholinergic signaling influence skilled reaching in mice, finding that ACh levels and outcome-dependent adjustments play roles in updating movement execution.

This study shows that a pathogenic AMPAR mutation impairs hippocampal synapse maturation and leads to metabolic adaptations over time.

BLIS-XL-MS enables proteome-wide analysis of structural remodeling in brain tissue by combining experimental and computational methods to study protein conformational changes in neurodevelopmental disorders.

This study shows that increased cognitive demand in mice enhances spatial activity in the suprapyramidal blade of the dentate gyrus, with specific roles for mature and adult-born granule cells.

This study shows that Fmr1 knockout mice exhibit exaggerated NMDA receptor-mediated metaplasticity due to SK channel dysregulation, affecting hippocampal LTP and potentially contributing to learning impairments in Fragile X syndrome.

This study shows that mGluR5 modulates co-activity of striatal direct pathway neurons and motor output through synaptic plasticity.

This study shows that an autism-linked mutation in Cacna1d causes perseverative behaviors in mice without affecting anxiety or locomotion.

Operant House is a low-cost, automated platform for operant conditioning testing in mice, revealing early working memory deficits in a Alzheimer's disease model.

The paper discovers that levetiracetam prevents Aβ42 production by modulating synaptic vesicle cycling, altering APP localization, and favoring non-amyloidogenic processing in Alzheimer's disease models.

This study uses human and mouse models to show that Kabuki syndrome mutations cause an imbalance in excitatory and inhibitory synapses, leading to synaptic dysfunction and intellectual disability.

The paper identifies Ca2+-dependent phosphodiesterase 1 (PDE1) as a regulator of NO-induced long-term depression (NO-LTD) in striatal spiny projection neurons, linking it to synaptic plasticity and Parkinson's disease.

This study investigates a missense mutation in the GRIK2 gene, showing it disrupts SK channel function, leading to increased dendritic excitability and synaptic integration in hippocampal neurons.

The paper investigates the neural mechanisms of antipsychotic drugs by comparing their effects on D1- and D2-receptor-expressing spiny-projection neurons in mice, finding that modulating D1-SPNs correlates with therapeutic efficacy.

This study identifies Gabra2 as a genetic modifier of Dravet syndrome in mice by showing that a deletion in Gabra2 worsens seizure and survival phenotypes in Scn1a+/- mice, which is reversed by repairing the deletion.

The paper shows that targeting α2 subunit-containing GABAA receptors with AZD7325 reduces seizures in Dravet syndrome mice without sedation.

This paper develops a method to create photoactivatable nicotine for optopharmacology studies of nicotinic acetylcholine receptors.