Author

John T. Welle

Providence Health & Services

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Brian PieningiD· 2 shared Andrew T. MagisiD· 1 shared Benjamin A. Cosgrove· 1 shared Brady M. BernardiD· 1 shared Carlo Bruno BifulcoiD· 1 shared David G. KirschiD· 1 shared Eric M. Shull· 1 shared Eric S. XuiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Brian PieningORCID

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Author profile →

2 papers

Recent·Most cited

A tailored in vivo CRISPR screen identifies BAP1 as a potent tumor suppressor of soft tissue sarcoma

Jianguo Huang, Xingliang Liu, Warren Floyd, William Haugh, Zhaoyu Sun, Melissa J. Kasiewicz, Yaping Wu, Brian Piening, John T. Welle, Wesley K. Rosales, Venkatesh Rajamanickam, So Young Kim, Eric S. Xu, Lixia Luo, Yan Ma, , David G. Kirsch

The paper identifies BAP1 as a tumor suppressor in soft tissue sarcoma using an in vivo CRISPR screen and shows that PLK1 inhibition can suppress tumor growth in BAP1-deficient models.

bioRxiv · Dec 5, 2025 · PreprintCancer Biology

Design and validation of a clinical whole genome sequencing-based assay for patient screening in a large healthcare system

Josiah T. Wagner, John T. Welle, Isabelle Lucas Beckett, Kate R. Emery, Benjamin A. Cosgrove, Krzysztof Olszewski, Nick Wagner, Tucker C. Bower, Li Chi Yuan, Eric M. Shull, Kathleen Jade, Jon Clemens, Andrew T. Magis, Mary B. Campbell, Ora Karp Gordon, , Brian Piening

The paper develops and validates a clinical whole genome sequencing assay for heritable disease and pharmacogenomics testing, showing high sensitivity, specificity, and accuracy in a large cohort.

Frontiers in Molecular Biosciences · Oct 13, 2025Peer-reviewedGenetic & Genomic Medicine