Brian Piening

The paper presents a longitudinal transcriptomic atlas of maternal peripheral blood during healthy pregnancy, identifying 720 pregnancy-specific genes and nine transcriptional modules associated with immune and metabolic changes.

The paper identifies BAP1 as a tumor suppressor in soft tissue sarcoma using an in vivo CRISPR screen and shows that PLK1 inhibition can suppress tumor growth in BAP1-deficient models.

The paper develops and validates a clinical whole genome sequencing assay for heritable disease and pharmacogenomics testing, showing high sensitivity, specificity, and accuracy in a large cohort.

APMAT analysis links CD8 T cell receptors, cognate antigens, and T cell phenotype/persistence using integrated experimental-computational methods.

This study shows that precision therapies have become more common than traditional chemotherapy in advanced cancer patients after implementing comprehensive genomic profiling.

The paper analyzes multi-omic data from two pig heart xenografts in human decedents to identify immune and metabolic responses associated with rejection and injury.

iNetModels 2.0 provides an interactive platform for visualizing and exploring multi-omics associations in human health and disease.