Ultra-large targeted DNA integrations in primary human cells
Courtney Kernick, Lauren Chow, Mikail Alejandro, Ke Li, Maxwell Gabriel Foisey, Xiaoyu Yang, Claire E. Hilburger, Johnathan Lu, Lujing Wu, Alison K. McClellan, Oliver Takacsi-Nagy, Rocco Brajenovic, Nicole E. Theberath, Emily Celallos Fuentes, Erin Lin, , Theodore L. Roth
This paper identifies methods to achieve ultra-large DNA integrations (>10 kb) in human cells with high efficiency using optimized templates and delivery strategies.
bioRxiv · Apr 9, 2026 · PreprintGenetics