Author

Xiaoyu Yang

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioengineering· 1 Genetics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:deconvolution· 1 Research Focus:drug response / drug discovery· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Brian Rudolph ShyiD· 2 shared Claire E. Hilburger· 2 shared Greg M. AlleniD· 2 shared Kole T. RoybaliD· 2 shared Maxwell Gabriel FoiseyiD· 2 shared Ricardo AlmeidaiD· 2 shared Alejandro Chaves-Martinez· 1 shared Alison K. McClellan· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenetics

Brian Rudolph ShyORCID

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Author profile →

4 papers

Recent·Most cited

Ultra-large targeted DNA integrations in primary human cells

Courtney Kernick, Lauren Chow, Mikail Alejandro, Ke Li, Maxwell Gabriel Foisey, Xiaoyu Yang, Claire E. Hilburger, Johnathan Lu, Lujing Wu, Alison K. McClellan, Oliver Takacsi-Nagy, Rocco Brajenovic, Nicole E. Theberath, Emily Celallos Fuentes, Erin Lin, , Theodore L. Roth

This paper identifies methods to achieve ultra-large DNA integrations (>10 kb) in human cells with high efficiency using optimized templates and delivery strategies.

bioRxiv · Apr 9, 2026 · PreprintGenetics

Synthetic Hybrid Receptors for Safer and Programmable T Cell Therapy

Maxwell Gabriel Foisey, Julie M. Garcia, Xun Li, Xiaoyu Yang, Claire E. Hilburger, Chloë Thienpont, Alejandro Chaves-Martinez, Serkan Belkaya, Tina Truong, Iowis Zhu, Raymond Liu, Axel Hyrenius Wittsten, Ricardo Almeida, Brian Rudolph Shy, Greg M. Allen, , Kole T. Roybal

This paper introduces Hybrid Receptors (Hybrid-Rs) to improve T cell therapy safety and programmability by combining CAR and SNIPR features for controlled gene regulation and reduced toxicity.

bioRxiv · Jan 23, 2026 · PreprintBioengineering

Cell-type specific inference from bulk RNA-sequencing data by integrating single cell reference profiles via EPIC-unmix

Chenwei Tang, Quan Sun, Xinyue Zeng, Gang Li, Xiaoyu Yang, Fei Liu, Jinying Zhao, Yin Shen, Boxiang Liu, Jia Wen, Yun Li

EPIC-unmix improves cell-type specific analysis from bulk RNA-seq by integrating single-cell reference profiles, identifying novel genes and eQTLs in Alzheimer's disease.

Genome biology · Nov 20, 2025Peer-reviewedGenomics

Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits

Xiaoyu Yang, Giancarlo La Camera

This study shows that a local plasticity rule in a spiking neural network can generate metastable dynamics and maintain synaptic stability while allowing plasticity for sensory representation remapping.

PLoS Computational Biology · Jul 1, 2024Peer-reviewedNeuroscience