Courtney Kernick

The paper identifies SLC7A1 as the transporter for cGAMP and its analogs in T cells, showing that targeting this transporter can reduce toxicity without affecting arginine transport.

SO_SCPLOWTACKC_SCPLOW is a foundation model trained on human single-cell data that enables in-context learning for predicting perturbation effects without fine-tuning.

This paper identifies methods to achieve ultra-large DNA integrations (>10 kb) in human cells with high efficiency using optimized templates and delivery strategies.

CRISPR-All enables genome-scale, combinatorial genetic perturbations in human cells, revealing additive functional improvements through multiplexed modifications.

The paper shows cancer cells redistribute mitochondria to sustain immunosuppressive ecosystems, reprogramming immune cells and enhancing their own metabolic resilience.

This study engineers recombinases to improve DNA insertion efficiency and specificity in human cells, achieving 53% integration and 97% genome-wide specificity.

This paper introduces non-viral intron targeting to improve genetic editing flexibility and simplify cell selection by integrating synthetic exons into endogenous introns.

This paper designs novel transcription factors using evolutionary principles to generate T cell states with enhanced functionality.