Small nuclear RNAs enhance protein-free RNA-programmable base conversion on mammalian coding transcripts
Aaron A. Smargon, Deepak Pant, Trent A. Gomberg, Christian R. Fagre, Sofia Glynne, Johnathan Nguyen, Jack T. Naritomi, Wendy V. Gilbert, Gene Wei-Ming Yeo
This study shows that guided A>I snRNAs improve RNA base conversion efficiency and reduce off-target effects compared to ADAR-recruiting circular RNAs in human cells.
Nature Chemical Biology · Sep 18, 2025Peer-reviewedBiochemistry