Author

Trent A. Gomberg

University of California San DiegoORCID 0000-0002-0600-2301Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Aaron A. SmargoniD· 2 shared Gene Wei-Ming YeoiD· 2 shared Christian R. FagreiD· 1 shared Deepak PantiD· 1 shared Deepak PantiD· 1 shared Dominic Paul LeeiD· 1 shared Don W. ClevelandiD· 1 shared Esaul Garcia· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Aaron A. SmargonORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Dual-targeting snRNA gene therapy rescues STMN2 and UNC13A splicing in TDP-43 proteinopathies

Trent A. Gomberg, Sara Elmsaouri, Hema Kopalle, Michael W. Baughn, Melinda S. Beccari, Melissa McAlonis‐Downes, Jonathan W. Artates, Deepak Pant, Harriet Mak, Aaron A. Smargon, Tynan C. Sander, Esaul Garcia, Dominic Paul Lee, Don W. Cleveland, Gene Wei-Ming Yeo

This study develops a gene therapy strategy using snRNAs to correct mis-splicing of STMN2 and UNC13A in TDP-43 proteinopathies, showing restoration of protein levels and axonal regeneration in motor neurons.

bioRxiv · Dec 3, 2025 · PreprintNeuroscience

Small nuclear RNAs enhance protein-free RNA-programmable base conversion on mammalian coding transcripts

Aaron A. Smargon, Deepak Pant, Trent A. Gomberg, Christian R. Fagre, Sofia Glynne, Johnathan Nguyen, Jack T. Naritomi, Wendy V. Gilbert, Gene Wei-Ming Yeo

This study shows that guided A>I snRNAs improve RNA base conversion efficiency and reduce off-target effects compared to ADAR-recruiting circular RNAs in human cells.

Nature Chemical Biology · Sep 18, 2025Peer-reviewedBiochemistry