The Critical Role of the C-terminal Lobe of Calmodulin in Activating Eukaryotic Elongation Factor 2 Kinase
Kimberly J. Long, Luke Samuel Browning, Andrea Piserchio, Eta A. Isiorho, Mohamed I. Gadallah, Jomai Douangvilay, Elizabeth Y Wang, Justin K. Kalugin, Jennifer S. Brodbelt, Ranajeet Ghose, Kevin N. Dalby
This study shows that the C-terminal lobe of calmodulin can fully activate eEF-2K independently of Ca2+ and external CaM, revealing a unique activation mechanism.
Journal of Biological Chemistry · Aug 28, 2025Peer-reviewedBiochemistry