Jennifer S. Brodbelt

The paper surveys the biosynthetic potential of the human tumor microbiome, identifying novel metabolites and their potential roles in tumor pathology.

The paper develops a fluorescent reporter, SeARCh, to quantify selenocysteine incorporation and reports a hybrid biosynthetic pathway achieving 90% Sec incorporation.

The paper identifies mutations in smURFP that significantly increase in vivo fluorescence in E. coli through deep mutational scanning and biophysical analysis.

This study shows Fc-silencing mutations in therapeutic antibodies do not block FCRL5 binding, potentially affecting B cell function through novel Fc-FCRL5 interactions.

This paper identifies the mechanism of color change in DNA/AgNC substrates upon nucleolytic cleavage and demonstrates their application in sensitive virus detection.

The paper defines the minimal sequence requirements of RNA polymerase II CTD across transcriptional stages using structural analysis and synthetic constructs, revealing a 'zipper' model for PIC assembly and transcription progression.

This study shows that the C-terminal lobe of calmodulin can fully activate eEF-2K independently of Ca2+ and external CaM, revealing a unique activation mechanism.

This paper develops a L-DOPA sensing system and improves biosynthesis via directed evolution, achieving high-efficiency incorporation into proteins.

This study shows that phosphate limitation in Gram-negative ESKAPE pathogens triggers alternative lipid synthesis, enabling antibiotic tolerance through reduced interaction with cationic antimicrobial peptides.

This paper identifies a PmrAB-independent mechanism of colistin heteroresistance in Enterobacter cloacae involving PhoPQEcl-mediated addition of 4-amino-4-deoxy-l-arabinose to lipid A.