Inflammasome-Inhibiting Nanoligomers are Neuroprotective Against Space-Induced Pathology in Healthy and Diseased 3D Human Motor and Pre-Frontal Cortex Brain Organoids
Sadhana Sharma, Vincenzo S. Gilberto, Jon C. Rask, Anushree Chatterjee, Prashant Nagpal
The paper demonstrates that nanoligomers targeting NF-κB and IL-6 mitigate space-induced neurodegeneration in brain organoids, showing potential for neuroprotective countermeasures and drug screening.
bioRxiv · Mar 19, 2024 · PreprintNeuroscience