Sadhana Sharma

Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model

This paper demonstrates that inflammasome-inhibiting Nanoligomers reduce neuroinflammation and improve outcomes in an EAE mouse model of MS.

Targeting neuroinflammation by pharmacologic down-regulation of inflammatory pathways is neuroprotective in protein misfolding disorders.

This paper shows that targeting neuroinflammation by down-regulating NF-κB and NLRP3 with SB_NI_112 protects against neurodegeneration in prion disease models.

Inflammasome-Inhibiting Nanoligomers are Neuroprotective Against Space-Induced Pathology in Healthy and Diseased 3D Human Motor and Pre-Frontal Cortex Brain Organoids

The paper demonstrates that nanoligomers targeting NF-κB and IL-6 mitigate space-induced neurodegeneration in brain organoids, showing potential for neuroprotective countermeasures and drug screening.

Brain-Penetrant NF-κB and NLRP3 Targeting Nanoligomers are Therapeutic in Amyotrophic Lateral Sclerosis (ALS) and Alzheimers Disease (AD) Human Organoid and Mouse Models

This paper demonstrates that NI112, a brain-penetrant Nanoligomer targeting NF-κB and NLRP3, improves functional outcomes and reduces neuroinflammation in ALS and AD human organoid and mouse models.

Microbiome- and Host Inflammasome-Targeting Inhibitor Nanoliogmers are Therapeutic in Murine Colitis Model

This paper develops and tests two Nanoligomer-based therapies, CK1 and NI112, for IBD in mice, showing reduced disease severity and biomarker expression.

Large- and Small-Animal Studies of Safety, Pharmacokinetics (PK), and Biodistribution of Inflammasome-Targeting Nanoligomer in the Brain and Other Target Organs

This paper evaluates the safety, pharmacokinetics, and biodistribution of an inflammasome-targeting Nanoligomer cocktail in small and large animals across multiple administration routes.

Screening Immunotherapy Targets to Counter Radiation-Induced Neuroinflammation

The paper identifies a Nanoligomer molecule that downregulates GM-CSF to reverse radiation-induced neuroinflammation in a mouse model.

Identifying Optimal Neuroinflammation Treatment Using Nanoligomer Discovery Engine

This paper develops a nanoligomer-based therapy to treat neuroinflammation by targeting key inflammatory pathways, showing effectiveness in a mouse model.

Reversing Radiation-Induced Immunosuppression Using a New Therapeutic Modality

This paper presents a high-throughput drug-discovery approach using Nanoligomer molecules to reverse radiation-induced immunosuppression by modulating gene expression and pathways.

The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection

The paper identifies miR-2392 as a miRNA involved in SARS-CoV-2 infection, showing its role in inflammation, glycolysis, and hypoxia, and develops a miRNA-based therapeutic targeting it.