Prashant Nagpal

This paper demonstrates that inflammasome-inhibiting Nanoligomers reduce neuroinflammation and improve outcomes in an EAE mouse model of MS.

This paper shows that targeting neuroinflammation by down-regulating NF-κB and NLRP3 with SB_NI_112 protects against neurodegeneration in prion disease models.

The paper demonstrates that nanoligomers targeting NF-κB and IL-6 mitigate space-induced neurodegeneration in brain organoids, showing potential for neuroprotective countermeasures and drug screening.

This paper demonstrates that NI112, a brain-penetrant Nanoligomer targeting NF-κB and NLRP3, improves functional outcomes and reduces neuroinflammation in ALS and AD human organoid and mouse models.

This study shows that binge ethanol increases NLRP3+ microglia in aged mice, and that Nanoligomer therapy reduces ethanol-induced neuroinflammation and tau hyperphosphorylation.

This paper develops and tests two Nanoligomer-based therapies, CK1 and NI112, for IBD in mice, showing reduced disease severity and biomarker expression.

This paper evaluates the safety, pharmacokinetics, and biodistribution of an inflammasome-targeting Nanoligomer cocktail in small and large animals across multiple administration routes.

The paper identifies a Nanoligomer molecule that downregulates GM-CSF to reverse radiation-induced neuroinflammation in a mouse model.

This paper develops a nanoligomer-based therapy to treat neuroinflammation by targeting key inflammatory pathways, showing effectiveness in a mouse model.

This paper presents a high-throughput drug-discovery approach using Nanoligomer molecules to reverse radiation-induced immunosuppression by modulating gene expression and pathways.

The paper identifies miR-2392 as a miRNA involved in SARS-CoV-2 infection, showing its role in inflammation, glycolysis, and hypoxia, and develops a miRNA-based therapeutic targeting it.

BOCS identifies genetic biomarkers using k-mer content analysis at low sequencing coverage with high accuracy for antibiotic resistance and cancer genes.