Anushree Chatterjee

This paper demonstrates that inflammasome-inhibiting Nanoligomers reduce neuroinflammation and improve outcomes in an EAE mouse model of MS.

This paper shows that targeting neuroinflammation by down-regulating NF-κB and NLRP3 with SB_NI_112 protects against neurodegeneration in prion disease models.

The paper demonstrates that nanoligomers targeting NF-κB and IL-6 mitigate space-induced neurodegeneration in brain organoids, showing potential for neuroprotective countermeasures and drug screening.

This paper demonstrates that NI112, a brain-penetrant Nanoligomer targeting NF-κB and NLRP3, improves functional outcomes and reduces neuroinflammation in ALS and AD human organoid and mouse models.

This study shows that binge ethanol increases NLRP3+ microglia in aged mice, and that Nanoligomer therapy reduces ethanol-induced neuroinflammation and tau hyperphosphorylation.

This paper develops and tests two Nanoligomer-based therapies, CK1 and NI112, for IBD in mice, showing reduced disease severity and biomarker expression.

This paper evaluates the safety, pharmacokinetics, and biodistribution of an inflammasome-targeting Nanoligomer cocktail in small and large animals across multiple administration routes.

The paper identifies a Nanoligomer molecule that downregulates GM-CSF to reverse radiation-induced neuroinflammation in a mouse model.

This paper develops a nanoligomer-based therapy to treat neuroinflammation by targeting key inflammatory pathways, showing effectiveness in a mouse model.

This paper presents a high-throughput drug-discovery approach using Nanoligomer molecules to reverse radiation-induced immunosuppression by modulating gene expression and pathways.

The paper identifies miR-2392 as a miRNA involved in SARS-CoV-2 infection, showing its role in inflammation, glycolysis, and hypoxia, and develops a miRNA-based therapeutic targeting it.

This study demonstrates that transcriptional interference can be controlled through RNA polymerase processivity using antitermination strategies, enabling gene repression and logic gate design.

This study explores the use of transcriptional interference to engineer two-input logic gates, showing how protein dissociation constants and promoter distances affect gate behavior.

This paper identifies gene expression perturbations that enhance antibiotic efficacy against MDR bacteria without fitness costs, demonstrating therapeutic potential in both E. coli and Salmonella.