Novel retinoic acid receptor-related orphan receptor gamma inverse agonist enhances checkpoint blockade in hepatocellular carcinoma: a preclinical mouse study
Sabrina Leo, Iqraa Dhoparee‐Doomah, Sarita Negi, Ahmed Fouda, France Bourdeau, Gertruda Evaristo, Steven Paraskevas, Jonathan Cools-Lartigue, Jean Tchervenkov
This study shows that inhibiting RORgamma enhances PD-L1 blockade efficacy in HCC by reducing neutrophil recruitment and increasing PD-L1 expression.
bioRxiv · Oct 24, 2026 · PreprintCancer Biology