France Bourdeau

This study shows that neutrophil extracellular traps (NETs) in lymph nodes create an immunosuppressive environment that promotes metastasis by altering Treg and CD8 T cell function and organization.

This study shows that inhibiting RORgamma enhances PD-L1 blockade efficacy in HCC by reducing neutrophil recruitment and increasing PD-L1 expression.

This study shows that RORγ inverse agonism reduces tumor progression by altering myeloid cell organization and immune responses in gastroesophageal adenocarcinoma.

This study links circulating myeloid dysfunction, measured by cNLR, to tumour spatial organization in GEA through multiscale analyses of immune function, single-cell transcriptomics, and spatial myeloid organization.

The paper establishes a large-scale biobank of GEA patient-derived organoids that accurately model tumor features and drug responses, enabling personalized treatment strategies.