Sabrina Leo

Novel retinoic acid receptor-related orphan receptor gamma inverse agonist enhances checkpoint blockade in hepatocellular carcinoma: a preclinical mouse study

This study shows that inhibiting RORgamma enhances PD-L1 blockade efficacy in HCC by reducing neutrophil recruitment and increasing PD-L1 expression.

RORγ Inverse Agonism Redirects Tumour-Conditioned Emergency Myelopoiesis and Attenuates Established Tumour Progression

This study shows that RORγ inverse agonism reduces tumor progression by altering myeloid cell organization and immune responses in gastroesophageal adenocarcinoma.

A Measurable Systemic Immune Phenotype Links Circulating Myeloid Dysfunction to Tumour Spatial Organization in Gastroesophageal Adenocarcinoma

This study links circulating myeloid dysfunction, measured by cNLR, to tumour spatial organization in GEA through multiscale analyses of immune function, single-cell transcriptomics, and spatial myeloid organization.