Author

Jonathan Desponds

Primary ORCID profile (0000-0001-7112-3217 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Jonathan DespondsiD2 papers · Genentech

Biology Disciplines

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Immunology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Thierry MoraiD· 2 shared Aleksandra M Walczak· 1 shared Aleksandra M. WalczakiD· 1 shared Aleksandra Walczak· 1 shared Andreas Mayer· 1 shared Aurelien Guillou· 1 shared Carmina Perez Romero· 1 shared Cecile Fradin· 1 shared

Activity by Year

2015-2017 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

Thierry MoraORCID

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Author profile →

3 papers

Recent·Most cited

Population dynamics of immune repertoires

Jonathan Desponds, Andreas Mayer, Thierry Mora, Aleksandra M. Walczak

This study uses mathematical models informed by experiments to show that memory immune repertoire evolution is non-neutral, driven by pathogenic history, while naive repertoires follow neutral dynamics.

bioRxiv · Mar 1, 2017 · PreprintImmunology

Precision of readout at the hunchback gene

Jonathan Desponds, Huy Tran, Teresa Ferraro, Tanguy Lucas, Carmina Perez Romero, Aurelien Guillou, Cecile Fradin, Mathieu Coppey, Nathalie Dostatni, Aleksandra M Walczak

The paper studies transcription dynamics of the hunchback gene in Drosophila embryos using imaging data and identifies bursty transcription initiation and low expression precision.

bioRxiv · Jul 14, 2016Developmental Biology

Fluctuating fitness shapes the clone size distribution of immune repertoires

Jonathan Desponds, Thierry Mora, Aleksandra Walczak

The paper models immune clone size distributions using fitness fluctuations and shows how these fluctuations explain universal power law patterns across different tissues and organisms.

bioRxiv · Jul 5, 2015Immunology