Huy Tran

The paper uses imaging and modeling to study transient leaks in epithelial tight junctions, finding that dynamic strand breaking and sealing explain leak behavior at the junction level.

The paper identifies CXXC4 as an epigenetic target that can restore DRD1 striatal neuron activity in Huntington disease by leveraging age-related gene patterns.

This study shows that substrate viscoelasticity influences how cells sense mechanical deformation through calcium signals, with stiff substrates producing stronger responses and distinct force dynamics.

EyeHex automates segmentation of Drosophila compound eyes from images, providing accurate metrics on ommatidia structure across different strains and image types.

The paper shows that the Bicoid-hunchback system's transcription dynamics can be explained by an equilibrium model with Bicoid as the sole positional information source, with Zelda and Hunchback modulating the process.

The paper measures Bicoid morphogen concentration dynamics in fruit fly embryos using a modified MS2-MCP reporter and shows that a 750 bp promoter region can recapitulate endogenous expression with high precision within 3 minutes.

The paper studies transcription dynamics of the hunchback gene in Drosophila embryos using imaging data and identifies bursty transcription initiation and low expression precision.