Nathalie Dostatni

EyeHex automates segmentation of Drosophila compound eyes from images, providing accurate metrics on ommatidia structure across different strains and image types.

This study compares the nuclear dynamics of Bicoid and Capicua in Drosophila embryos, finding they form similar oligomeric clusters despite opposing transcriptional roles.

The paper shows that the Bicoid-hunchback system's transcription dynamics can be explained by an equilibrium model with Bicoid as the sole positional information source, with Zelda and Hunchback modulating the process.

The paper examines the challenges in quantitatively modeling transcriptional regulation by the Bicoid gradient, emphasizing the role of bursty transcription dynamics.

The paper measures Bicoid morphogen concentration dynamics in fruit fly embryos using a modified MS2-MCP reporter and shows that a 750 bp promoter region can recapitulate endogenous expression with high precision within 3 minutes.

The paper studies transcription dynamics of the hunchback gene in Drosophila embryos using imaging data and identifies bursty transcription initiation and low expression precision.