Discovery of an autoimmunity-associated IL2RA enhancer by unbiased targeting of transcriptional activation
Dimitre R. Simeonov, Benjamin G. Gowen, Mandy Y. Boontanrart, Theodore L. Roth, Youjin Lee, Alice Y. K. Chan, Michelle Ly Thai Nguyen, Rachel E. Gate, Meena Subramaniam, Jonathan M. Woo, Therese Mitros, Graham J. Ray, Nicolas Bray, Gemma L. Curie, Nicki Naddaf, , Alexander Marson
The paper identifies an IL2RA enhancer associated with autoimmunity using CRISPRa and shows it affects gene activation timing without blocking expression.
bioRxiv · Dec 5, 2016 · PreprintGenetics