Bidirectional Control of Coronary Vascular Resistance by Eicosanoids via a Novel GPCR
Nabil J. Alkayed, Zhiping Cao, Zu Yuan Qian, Shanthi Nagarajan, Xuehong Liu, Jonathan Nelson, Fuchun Xie, Bingbing Li, Wei Fan, Lijuan Liu, Marjorie R. Grafe, Xiangshu Xiao, Anthony P. Barnes, Sanjiv Kaul
The paper identifies GPR39 as a microvascular smooth muscle cell receptor regulated by opposing eicosanoids, 15-HETE and 14,15-EET, which modulate coronary vascular resistance through distinct mechanisms.
bioRxiv · Sep 19, 2018 · PreprintPhysiology