Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome
Saad B. Hannan, Ivan Alić, Aoife Murray, Joonhong Kwon, Martin Mortensen, Hyo Jung Kang, Ante Plećaš, Pollyanna Agnes Goh, Niamh Louise O’Brien, Richard Naud, Dean Nižetić, Trevor G. Smart
This study shows that trisomy 21 impairs cortical circuit development by disrupting synaptic connectivity and intrinsic membrane properties in neurons.
Nature Communications · Jan 22, 2026Peer-reviewedNeuroscience