Author

Pollyanna Agnes Goh

Queen Mary University of LondonORCID 0000-0002-6244-7428Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Assay:proteomics· 1

Frequent Co-Authors

Aoife MurrayiD· 2 shared Dean NižetićiD· 2 shared Ivan AlićiD· 2 shared Niamh Louise O’BrieniD· 2 shared Agueda A. RostagnoiD· 1 shared André StrydomiD· 1 shared Anne Rovelet‐LecruxiD· 1 shared Annette Karmiloff‐Smith· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersNeuroscience

Aoife MurrayORCID

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2 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedJan 22, 2026

Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome

Saad B. Hannan, Ivan Alić, Aoife Murray…·Trevor G. Smart

This study shows that trisomy 21 impairs cortical circuit development by disrupting synaptic connectivity and intrinsic membrane properties in neurons.

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humanelectronic health records

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NeuroscienceMolecular PsychiatryPeer-reviewedJul 9, 2020

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain

Ivan Alić, Pollyanna Agnes Goh, Aoife Murray…·Henrik Zetterberg

The paper shows that trisomy 21 cerebral organoids exhibit AD-like pathology, which can be suppressed by BACE2 trisomy and inhibited by BACE1 inhibitors, suggesting BACE2 as an AD-suppressor gene.

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humanproteomics

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