Saad B. Hannan

This study shows that trisomy 21 impairs cortical circuit development by disrupting synaptic connectivity and intrinsic membrane properties in neurons.

The paper investigates GABA inhibition in Down syndrome mouse models, finding circuit-specific increases in inhibition in the dentate gyrus due to gene dosage effects.

This study identifies gain-of-function GABAAR variants in GABRA1 that increase GABAergic signaling and reduce dendritic spine density, which can be reversed by the neurosteroid pregnenolone sulphate.

This study identifies PKA-mediated phosphorylation of Neuroligin-2 as a mechanism regulating its synaptic stabilisation and GABAAR concentration.