Epistasis limits but does not prevent the transfer of mutation-drug resistance mapping across 600 million years of fungal evolution
Marie-Ève Picard, Romain Durand, Alexandre K. Dubé, Soham Dibyachintan, Alicia Pageau, Philippe C Després, Emilie M. M. Alexander, Jordan Grenier, Rong Shi, Christian R. Landry
The paper shows that resistance mutations to antifungal drugs are conserved across fungal species but epistasis limits their transferability.
bioRxiv · Jul 8, 2026 · PreprintMicrobiology