Soham Dibyachintan

The hydrophobicity of peptides limits their availability to bind to interacting domains

The paper identifies that peptide hydrophobicity affects their availability in yeast cells, impacting synthetic interaction strength beyond in vitro measurements.

Epistasis limits but does not prevent the transfer of mutation-drug resistance mapping across 600 million years of fungal evolution

The paper shows that resistance mutations to antifungal drugs are conserved across fungal species but epistasis limits their transferability.

Phenotypic dominance emerges from activity-fitness functions and molecular interactions

The paper examines how molecular interactions and activity-fitness functions determine phenotypic dominance in homomeric proteins.

Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network

The paper shows that mutations in protein binding domains, combined with regulatory divergence, determine the fate of gene duplicates in a protein interaction network.

Protein context shapes the specificity of domain-peptide interactions in vivo

The paper shows that SH3 domain specificity in PPIs is influenced by host protein identity and domain position, not just intrinsic domain properties.