SARS-CoV-2 EndoU-ribonuclease regulates RNA recombination and impacts viral fitness.
Yiyang Zhou, Yani P. Ahearn, Kumari G. Lokugamage, Angelica L. Morgan, R. Elias Alvarado, Leah K. Estes, William M. Meyers, Alyssa M. McLeland, Jordan T. Murray, Joseph R Rouse, Meenakshi Kar, Mehul S. Suthar, David Hughes Walker, Bryan A. Johnson, Andrew L. Routh, Vineet D. Menachery
This study shows SARS-CoV-2 NSP15 (EndoU) regulates RNA recombination and viral fitness, with its loss reducing replication but increasing inflammation and defective genomes.
Nature Communications · Dec 2, 2025Peer-reviewedMicrobiology