Yiyang Zhou

This study shows that disrupting both NSP3 and nucleocapsid SG antagonism reduces SARS-CoV-2 replication and disease, suggesting stress granule activation as a therapeutic target.

This study uses a new sequencing method to show that viral RNA is released in an ordered, conserved manner during virus disassembly, with specific genomic regions released first.

This study shows SARS-CoV-2 NSP15 (EndoU) regulates RNA recombination and viral fitness, with its loss reducing replication but increasing inflammation and defective genomes.

This study shows that the furin cleavage site (FCS) is essential for SARS-CoV-2 pathogenesis but not for transmission, as a mutant lacking FCS was transmissible in hamsters but caused less severe disease.

This study identifies an RNA-RNA heterodimer in Flock House virus that affects genome packaging and virion stability.

ViReMa is updated to detect recombination events in long-read sequencing data and reports various recombinant species in different viral contexts.

Tiled-ClickSeq enables complete SARS-CoV-2 genome sequencing with detection of RNA recombination and minority variants in a single assay.

This paper introduces PAR-CL, a method to identify RNA-capsid interactions in virus particles, and shows that these interactions occur preferentially in double-stranded RNA regions.