Mehul S. Suthar

Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses

This study evaluates antibody responses after a KP.2 spike mRNA vaccine dose, showing durable and broadly cross-reactive immunity against multiple SARS-CoV-2 variants, but reduced neutralizing activity against some emerging subvariants.

Wobble Vaccines: Complex Vaccine Antigen Pools Promote Increased Antibody Breadth and Cross-Strain Viral Targeting in SARS-CoV-2

Sustained Delivery of a SARS-CoV-2 Subunit Vaccine in An Adjuvanted Hydrogel Depot Enhances Vaccine Responses in Nonhuman Primates

This study shows that sustained delivery of a SARS-CoV-2 subunit vaccine in an adjuvanted hydrogel depot improves antibody responses in nonhuman primates compared to bolus vaccination.

Dirty mice better recapitulate key features of mRNA vaccine immunogenicity observed in humans

This study shows that dirty mice, with broad microbial exposure, better model human immune responses to SARS-CoV-2 mRNA vaccines, showing reduced antibody titers and faster waning compared to SPF mice.

Antagonism of stress granules key for SARS-CoV-2 infection and pathogenesis.

This study shows that disrupting both NSP3 and nucleocapsid SG antagonism reduces SARS-CoV-2 replication and disease, suggesting stress granule activation as a therapeutic target.

Antigenic characterization of SARS-CoV-2 variants BA.3.2.1 and BA.3.2.2 in three animal models

This study characterizes the antigenic properties of SARS-CoV-2 variants BA.3.2.1 and BA.3.2.2 in three animal models and finds they are antigenically divergent from existing variants with lower homologous serum titers.

IgG3 Hinge Architecture Expands Dengue Virus Breadth of A Quaternary Epitope Dependent Zika Virus Cross-Neutralizing Antibody

This study identifies an IgG3 subclass antibody that expands neutralization breadth against dengue and zika viruses by engaging a quaternary epitope through structural and functional analyses.

Altered neurodevelopment, CSF volume, and emotional reactivity following postnatal Zika virus infection in infant macaques

This study investigates the effects of postnatal Zika virus infection in infant macaques, finding altered neurodevelopment, increased emotional reactivity, and changes in CSF volume and brain structure.

Mechanisms of disrupted neurodevelopment after Zika virus infection in infancy

This study investigates the effects of Zika virus infection on infant brain development using single-cell transcriptomics and other methods, identifying disrupted pathways and behavioral changes.

SARS-CoV-2 EndoU-ribonuclease regulates RNA recombination and impacts viral fitness.

This study shows SARS-CoV-2 NSP15 (EndoU) regulates RNA recombination and viral fitness, with its loss reducing replication but increasing inflammation and defective genomes.

Homotypic endoplasmic reticulum membrane tethering is critical for flavivirus replication

This study identifies ATL2 as critical for flavivirus replication by organizing viral replication organelles and limiting immune activation.

FcγRI is the key determinant of antibody-mediated Zika virus infection of human placental macrophages

This study identifies FcγRI as the critical Fc receptor mediating antibody-enhanced ZIKV infection of placental macrophages through genetic and functional analyses.

The furin cleavage site is required for pathogenesis, but not transmission of SARS-CoV-2

This study shows that the furin cleavage site (FCS) is essential for SARS-CoV-2 pathogenesis but not for transmission, as a mutant lacking FCS was transmissible in hamsters but caused less severe disease.

Efficacy of late-onset antiviral treatment in immune-compromised hosts with persistent SARS-CoV-2 infection

This study evaluates late-onset antiviral treatment in immunocompromised mice with persistent SARS-CoV-2 infection, finding that 4-FlU significantly reduces virus load, while paxlovid causes viral rebound.

Eosinophils protect against SARS-CoV-2 following a vaccine breakthrough infection

The paper shows that eosinophils protect against SARS-CoV-2 in vaccinated mice during breakthrough infections by reducing viral burden and limiting dissemination.

Immunogenicity and protective efficacy of an influenza virus-like particle-based SARS-CoV-2 hybrid vaccine candidate in rhesus macaques

This study evaluates a hybrid vaccine combining influenza and SARS-CoV-2 antigens in rhesus macaques, showing strong immune responses and protection against SARS-CoV-2 infection.

Comparative Analysis of SARS-CoV-2 Antigenicity across Assays and in Human and Animal Model Sera

The paper compares SARS-CoV-2 antigenicity across assays and in human and animal model sera, finding similar immunodominance patterns and antigenic maps but differences in titer magnitude and assay-specific fold change.

Long-term alterations in brain and behavior after postnatal Zika virus infections in infant macaques

This study shows that postnatal Zika virus infection in infant macaques leads to long-term behavioral, motor, and cognitive deficits along with structural and functional brain changes.

Role of RIG-I-like receptors in innate immune sensing of Coxsackievirus B3 and encephalomyocarditis virus in murine macrophages and fibroblasts

The paper investigates how RIG-I and MDA5 sense Coxsackievirus B3 and encephalomyocarditis virus in macrophages and fibroblasts, showing cell-type dependent innate immune responses.