Dynamic Regulation Of The Chromatin Environment By ASH1L Modulates Human Neuronal Structure And Function
Megha Jhanji, Joseph A. Ward, Calvin S. Leung, Colleen L. Krall, Foster D. Ritchie, Alexis Guevara, Kai Vestergaard, Brian Yoon, Krishna Amin, Stefano Berto, Judy Shih-Hwa Liu, Sofia B. Lizarraga
This study shows that ASH1L mutations disrupt chromatin regulation, leading to neuronal dysfunction and disease-related gene dysregulation, and identifies potential therapeutic strategies.
bioRxiv · Dec 2, 2024 · PreprintNeuroscience