Author

Foster D. Ritchie

University of South CarolinaORCID 0000-0002-2185-8079Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Sofia B. LizarragaiD· 3 shared Judy Shih-Hwa LiuiD· 2 shared Mikayla M. McCordiD· 2 shared Seon Hye Cheon· 2 shared Alexis Guevara· 1 shared Allison M. Culver· 1 shared Anna M. BagnelliD· 1 shared Austin J. Smith· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Sofia B. LizarragaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dynamic Regulation Of The Chromatin Environment By ASH1L Modulates Human Neuronal Structure And Function

Megha Jhanji, Joseph A. Ward, Calvin S. Leung, Colleen L. Krall, Foster D. Ritchie, Alexis Guevara, Kai Vestergaard, Brian Yoon, Krishna Amin, Stefano Berto, Judy Shih-Hwa Liu, Sofia B. Lizarraga

This study shows that ASH1L mutations disrupt chromatin regulation, leading to neuronal dysfunction and disease-related gene dysregulation, and identifies potential therapeutic strategies.

bioRxiv · Dec 2, 2024 · PreprintNeuroscience

Overcoming the effect of ASH1L haploinsufficiency on stem cells amenability to genome editing and differentiation into the neuronal lineage - a technical report

Seon Hye Cheon, Foster D. Ritchie, Janay M. Vacharasin, Nicholas A. Marinelli, Collin Cheatle, Mikayla M. McCord, Kaitlin Cox, Sofia B. Lizarraga

This paper describes protocols to overcome ASH1L haploinsufficiency in stem cells, improving genome editing and neuronal differentiation efficiency.

bioRxiv · Sep 27, 2021 · PreprintNeuroscience

ASH1L REGULATES THE STRUCTURAL DEVELOPMENT OF NEURONAL CIRCUITRY BY MODULATING BDNF/TrkB SIGNALING IN HUMAN NEURONS

Seon Hye Cheon, Allison M. Culver, Anna M. Bagnell, Foster D. Ritchie, Janay M. Clytus, Mikayla M. McCord, Carin M. Papendorp, Evelyn Chukwurah, Austin J. Smith, Mara H. Cowen, Pankaj S. Ghate, Shannon William Davis, Judy Shih-Hwa Liu, Sofia B. Lizarraga

This study shows ASH1L regulates neuronal connectivity by modulating BDNF/TrkB signaling through its interaction with PRC2 in human neurons, linking ASH1L mutations to autism pathogenesis.

bioRxiv · Feb 18, 2020 · PreprintNeuroscience