Author

Calvin S. Leung

Brown UniversityORCID 0000-0003-4973-3646Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Calvin S. Leung1 paper · University of California, Los Angeles

Biology Disciplines

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Neuroscience· 2

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Brian Yoon· 2 shared Sofia B. LizarragaiD· 2 shared Abbie M. Maguire· 1 shared Alexis Guevara· 1 shared Colleen L. Krall· 1 shared Ece Dilber Gamsiz UzuniD· 1 shared Ethan W. HollingsworthiD· 1 shared Foster D. RitchieiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

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10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Brian Yoon

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintDec 2, 2024

Dynamic Regulation Of The Chromatin Environment By ASH1L Modulates Human Neuronal Structure And Function

Megha Jhanji, Joseph A. Ward, Calvin S. Leung…·Sofia B. Lizarraga

This study shows that ASH1L mutations disrupt chromatin regulation, leading to neuronal dysfunction and disease-related gene dysregulation, and identifies potential therapeutic strategies.

DOI 10.1101/2024.12.02.625500

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceHuman Molecular GeneticsPeer-reviewedJan 9, 2023

Dysregulation of The Chromatin Environment Leads to Differential Alternative Splicing as A Mechanism Of Disease In a Human Model of Autism Spectrum Disorders

Calvin S. Leung, Shoshana J. Rosenzweig, Brian Yoon…·Sofia B. Lizarraga

This study shows that VPA exposure alters chromatin environment, leading to changes in alternative splicing and gene expression in human cortical neurons, which may contribute to ASD pathogenesis.

15 citations

humanbulk RNA-seq

𝕏 PostBluesky