Author

Megha Jhanji

Brown UniversityORCID 0000-0002-4796-8209Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Sofia B. LizarragaiD· 3 shared Alexis Guevara· 2 shared Brian Yoon· 2 shared Colleen L. Krall· 2 shared Judy Shih-Hwa LiuiD· 2 shared Brian C. KavanaughiD· 1 shared Calvin S. LeungiD· 1 shared Carin M. PapendorpiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Sofia B. LizarragaORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintFeb 21, 2025

Mutations in ASH1L cause a neurodevelopmental disorder with sex differences in epilepsy and autism

Carin M. Papendorp, Elizabeth Nolan, Haruki Higashimori…·Judy Shih-Hwa Liu

This study identifies ASH1L mutations causing a neurodevelopmental disorder with sex-specific effects on epilepsy and autism in mice and humans.

1 citation

mouseelectronic health records

NeurosciencebioRxivPreprintDec 11, 2024

The intersection of inflammation and DNA damage as a novel axis underlying the pathogenesis of autism spectrum disorders

Megha Jhanji, Colleen L. Krall, Alexis Guevara…·Sofia B. Lizarraga

The paper investigates the molecular link between maternal inflammation and ASD by identifying a shared signature in human neurons exposed to IL-17A, suggesting DNA damage response defects contribute to ASD pathogenesis.

1 citation

humanbulk RNA-seq

NeurosciencebioRxivPreprintDec 2, 2024

Dynamic Regulation Of The Chromatin Environment By ASH1L Modulates Human Neuronal Structure And Function

Megha Jhanji, Joseph A. Ward, Calvin S. Leung…·Sofia B. Lizarraga

This study shows that ASH1L mutations disrupt chromatin regulation, leading to neuronal dysfunction and disease-related gene dysregulation, and identifies potential therapeutic strategies.

DOI 10.1101/2024.12.02.625500

humanbulk RNA-seq