Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-linked Parkinson's disease
D. J. Vidyadhara, Mahalakshmi Somayaji, Nigel Wade, Betül Yücel, Helen R. Zhao, N Shashaank, Joseph Ribaudo, Jyoti Gupta, TuKiet T. Lam, Dalibor Sameš, Lois E. Greene, David L. Sulzer, Sreeganga S. Chandra
This study shows that auxilin deficiency causes Parkinson's disease by disrupting dopamine transporter function and synaptic vesicle sorting, leading to dopamine homeostasis disruption and neurodegeneration.
Cell Reports · Mar 1, 2023Peer-reviewedNeuroscience