TuKiet T. Lam

Myosin 5A mediates membrane-associated periodic skeleton reassembly during axon regeneration in response to ROCK-2 inhibition

This study identifies MYO5A as a key mediator of MPS reassembly during axon regeneration, showing that ROCK-2 inhibition enhances regrowth and accelerates MPS recovery.

mPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model

The paper identifies proteomic changes in mPFC synaptosomes of mice exposed to inescapable stress, highlighting muscarinic receptor alterations and signaling pathway disruptions linked to depression.

Granulocyte colony-stimulating factor acts through calcium-permeable AMPA receptors to potentiate cocaine reward

This study shows that G-CSF enhances cocaine reward by promoting glutamatergic synaptic remodeling in the nucleus accumbens through calcium-permeable AMPA receptors.

Beyond the Genotype: A Multi-Omic Analysis of APOEe4's Role in Alzheimer's Disease

This paper investigates how APOEe4 influences molecular changes in Alzheimer's disease through proteomic, epigenetic, and genetic analyses of post-mortem brain samples, identifying key proteins and epigenetic markers associated with risk and resilience.

Anks3 mediates cilia dependent polycystin signaling and is essential for adult kidney homeostasis

This study identifies Anks3 as a key regulator of cilia-dependent polycystin signaling and shows its essential role in kidney homeostasis.

Growth Arrest of Thoracic Aortic Aneurysms in Aging Marfan Mice

The paper investigates growth arrest in thoracic aortic aneurysms of aging Marfan mice, identifying gene expression and proteomic changes that may contribute to disease stabilization.

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease

The paper uses subcellular proteomics and iPSC models to identify mTOR pathway activation in axonal spheroids and show its reversible role in Alzheimer's disease pathology.

Single-cell transcriptomic and proteomic analysis of Parkinson's disease Brains

The paper performs single-cell transcriptomic and proteomic analysis of Parkinson's disease brains, identifying cell-type-specific changes and differences from Alzheimer's disease.

DAB-APT: a Fluorescence-Based Assay for Determining Aminopropyl Transferase Activity and Inhibition

The paper develops a fluorescence-based assay, DAB-APT, to measure aminopropyl transferase activity and inhibition, validated with enzymes from S. cerevisiae and P. falciparum.

The hyperphosphorylation of SARS-CoV-2s nucleocapsid protein by GSK-3 involves a complex and redundant priming mechanism

This study reveals that SARS-CoV-2 nucleocapsid protein hyperphosphorylation by GSK-3 involves a complex, cooperative priming mechanism rather than simple sequential phosphorylation.

DOT1L bridges transcription and heterochromatin formation at pericentromeres

This study shows that DOT1L is essential for transcription of pericentromeric repeats and maintains genome stability by bridging transcription and heterochromatin formation.

Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome

This study examines how cocaine and morphine affect diurnal proteome rhythms in the mouse nucleus accumbens, revealing distinct pathway alterations.

Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-linked Parkinson's disease

This study shows that auxilin deficiency causes Parkinson's disease by disrupting dopamine transporter function and synaptic vesicle sorting, leading to dopamine homeostasis disruption and neurodegeneration.

Changes in gut microbiome composition drive fentanyl intake and striatal proteomic changes

This study shows that changes in gut microbiome composition influence fentanyl intake and striatal proteomic changes in a drug self-administration model.

A nuclear role for the Argonaute protein AGO2 in mammalian gametogenesis

This study identifies a nuclear role for AGO2 in spermatogenesis, showing it enhances protein expression by interacting with splicing and chromatin factors.

Inflammaging in human photoexposed skin: Early onset of senescence and imbalanced epidermal homeostasis across the decades.

The paper investigates inflammaging in human photoexposed skin, identifying early senescence and imbalanced epidermal homeostasis across age groups.

Granulocyte-Colony Stimulating Factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex

This study shows that G-CSF reduces cocaine-seeking behavior and alters glutamatergic synaptic proteins in the medial prefrontal cortex.

Identification of synaptic PPT1 substrates highlight roles of depalmitoylation in disulfide bond formation and synaptic function

The paper identifies PPT1 substrates in mouse brains, showing depalmitoylation's role in disulfide bond formation and synaptic function, with over 100 novel substrates found.