Sreeganga S. Chandra

The paper shows UV exposure causes misfolded melanosomal proteins to aggregate, contributing to skin pigmentation disorders and melanocyte dysfunction.

The paper performs single-cell transcriptomic and proteomic analysis of Parkinson's disease brains, identifying cell-type-specific changes and differences from Alzheimer's disease.

This study shows that GBA mutations cause cognitive deficits in Parkinson's disease and Dementia with Lewy Bodies through synaptic vesicle endocytosis defects, independent of alpha-synuclein pathology.

This study uses single nucleus transcriptomics to identify transcriptional changes in CSP KO mice, revealing repression of synaptic pathways and upregulation of autophagy in neurons, along with altered neuron-glia interactions.

This study shows that auxilin deficiency causes Parkinson's disease by disrupting dopamine transporter function and synaptic vesicle sorting, leading to dopamine homeostasis disruption and neurodegeneration.

This study investigates olfactory dysfunction in a mouse model of Parkinson's disease, finding that alpha-synuclein pathology and reduced neurogenesis in the olfactory bulb contribute to impaired olfaction.

The paper identifies PPT1 substrates in mouse brains, showing depalmitoylation's role in disulfide bond formation and synaptic function, with over 100 novel substrates found.

This study shows that α-synuclein facilitates clathrin assembly during synaptic vesicle endocytosis by increasing clathrin patch size and curvature.

This study develops a Drosophila model of CLN4 NCL, showing that CLN4 mutations cause hypermorphic gain of function through excessive oligomerization and impaired membrane trafficking.