Mahalakshmi Somayaji

This study shows that auxilin deficiency causes Parkinson's disease by disrupting dopamine transporter function and synaptic vesicle sorting, leading to dopamine homeostasis disruption and neurodegeneration.

The paper presents three computational models to analyze fast-scan cyclic voltammetry data from mice, quantifying presynaptic dopamine kinetics and the role of synucleins in neurotransmission.

This study shows α-synuclein enhances dopamine release during burst firing in substantia nigra neurons in vivo, independent of β- and γ-synucleins or presynaptic calcium.

This study maps the in vivo firing patterns of midbrain dopamine neurons based on their axonal projections, revealing functional diversity that challenges classical anatomical boundaries.