Author

Helen R. Zhao

Yale UniversityORCID 0000-0002-1333-9463Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Betül Yücel· 2 shared Sreeganga S. ChandraiD· 2 shared TuKiet T. LamiD· 2 shared D. J. VidyadharaiD· 1 shared Dalibor SamešiD· 1 shared David L. SulzeriD· 1 shared Erica L. GorenbergiD· 1 shared Gregory S. WirakiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Betül Yücel

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2 papers

Recent·Most cited

Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-linked Parkinson's disease

D. J. Vidyadhara, Mahalakshmi Somayaji, Nigel Wade, Betül Yücel, Helen R. Zhao, N Shashaank, Joseph Ribaudo, Jyoti Gupta, TuKiet T. Lam, Dalibor Sameš, Lois E. Greene, David L. Sulzer, Sreeganga S. Chandra

This study shows that auxilin deficiency causes Parkinson's disease by disrupting dopamine transporter function and synaptic vesicle sorting, leading to dopamine homeostasis disruption and neurodegeneration.

Cell Reports · Mar 1, 2023Peer-reviewedNeuroscience

Identification of synaptic PPT1 substrates highlight roles of depalmitoylation in disulfide bond formation and synaptic function

Erica L. Gorenberg, Sofia Massaro Tieze, Betül Yücel, Helen R. Zhao, Vicky Chou, Gregory S. Wirak, Susumu Tomita, TuKiet T. Lam, Sreeganga S. Chandra

The paper identifies PPT1 substrates in mouse brains, showing depalmitoylation's role in disulfide bond formation and synaptic function, with over 100 novel substrates found.

bioRxiv · May 2, 2020 · PreprintNeuroscience