A human sensory neuron model for varicella-zoster virus latency and reactivation in vitro.
Alexander C. Havelaar, Joseph S. Flot, Saori Fukuda, Anja W. M. de Jong, Roman I. Koning, Amber J. Schotting, Sem van ’t Geloof, Tomohiko Sadaoka, Georges M. G. M. Verjans, Paul R. Kinchington, Werner J. D. Ouwendijk
This paper establishes HD10.6 neurons as an in vitro model for studying VZV latency and reactivation, showing they support viral infection, persistence, and reactivation with capsaicin.
bioRxiv · Dec 12, 2025 · PreprintMicrobiology