Author

Paul R. Kinchington

University of PittsburghORCID 0000-0002-1901-9970Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Ajay KumariD· 1 shared Alexander C. HavelaariD· 1 shared Amber J. SchottingiD· 1 shared Anja W. M. de JongiD· 1 shared Eman E. Taher· 1 shared Enzhi Yang· 1 shared Georges M. G. M. VerjansiD· 1 shared Jennifer F. MoffatiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

Ajay KumarORCID

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3 papers

Recent·Most cited

Fixed Nonsynonymous vOka Mutations in IE62 Drive Varicella-Zoster Virus Attenuation in Human Skin

Reuben O. Onwe, Joao Ramos Ferreira, Megan G. Lloyd, Joseph Flot, Paul R. Kinchington, Jennifer F. Moffat

This study identifies specific SNPs in VZV that contribute to vaccine strain attenuation by analyzing their effects on viral growth and skin pathology in human skin organ cultures.

bioRxiv · Sep 28, 2026 · PreprintMicrobiology

A human sensory neuron model for varicella-zoster virus latency and reactivation in vitro.

Alexander C. Havelaar, Joseph S. Flot, Saori Fukuda, Anja W. M. de Jong, Roman I. Koning, Amber J. Schotting, Sem van ’t Geloof, Tomohiko Sadaoka, Georges M. G. M. Verjans, Paul R. Kinchington, Werner J. D. Ouwendijk

This paper establishes HD10.6 neurons as an in vitro model for studying VZV latency and reactivation, showing they support viral infection, persistence, and reactivation with capsaicin.

bioRxiv · Dec 12, 2025 · PreprintMicrobiology

Stem Cell Transplantation Rescued A Primary Open-Angle Glaucoma Mouse Model

Siqi Xiong, Ajay Kumar, Shenghe Tian, Eman E. Taher, Enzhi Yang, Paul R. Kinchington, Xiaobo Xia, Yiqin Du

This study shows that transplanting human trabecular meshwork stem cells (TMSCs) reduces intraocular pressure and protects retinal ganglion cells in a glaucoma mouse model.

eLife · Jan 28, 2021Peer-reviewedCell Biology