A connexin 43 targeting peptide prevents blood vessel neointima formation
Mark C. Renton, Meghan W. Sedovy, Xinyan Leng, Farwah Iqbal, Melissa R. Leaf, Kailynn Roberts, Ramya C. Joshi, Arya Malek, Clare L. Dennison, Angela K. Best, Paul D. Lampe, Joseph W. Baker, Mark Joseph, George S. Baillie, Brant E. Isakson, Scott R. Johnstone
This study identifies a Cx43 targeting peptide that inhibits neointima formation in both human and mouse models by blocking cyclin E interactions and cell cycle progression.
bioRxiv · Sep 22, 2025 · PreprintPhysiology